雌激素的功能是促进性器官的发育和成熟、维持第二性征, 以及对内分泌功能的调节。已发现雌激素的功能并不局限于生殖系统,它也能够影响神经系统的功能,并具有一定的神经保护作用。 1雌激素受体雌激素与其他甾体类激素一样,通常通过细胞内受体发挥其生物学效应,已知的雌激素受体(estrogen receptor,ER)与其它甾体类激素同属一个受体超家族成员。这类受体大多需要与配体结合活化,然后进入核内,与靶基因中特异的激素反应成 The function of estrogen is to promote the development and maturation of sexual organs, maintain the secondary sexual characteristics, and regulate endocrine function. It has been found that the function of estrogen is not limited to the reproductive system, it can also affect the nervous system function, and has some neuroprotective effect. Estrogen Receptors Estrogens, like other steroid hormones, exert their biological effects, usually via intracellular receptors. The known estrogen receptor (ER), which belongs to the same receptor as other steroid hormones, Superfamily members. Most of these receptors need to activate ligand binding, and then enter the nucleus, and the target gene specific hormone response into