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背景:遗传多态性短串联重复序列(short tandem repeats,STRs)分析是用于检测基因型和表型之间关联的公认方法 ,但它以前没有在冲动攻击行为的遗传学研究中使用。目的 :在有冲动攻击行为史的男性和无冲动攻击行为史的男性对照组之间,比较15个STR基因位点(D8S1179,D21S11,D7S820,CSF1PO,D3S1358,TH01,D13S317,D16S539,D2S1338,D19S433,vWA,TPOX,D18S51,D5S818和FGA)不同多态性的发生率。方法 :应用AmpFlSTR?Identifiler?试剂盒比较407个有冲动性攻击行为的案例和415个对照的15个STR基因位点等位基因的分布。结果 :有冲动攻击行为史的男性以下等位基因的平均频率显著低于对照组:TH01的等位基因10(OR=0.29,95%CI=0.16-0.52,p<0.0001),TPOX的等位基因8(OR=0.71,95%CI=0.58-0.86,p=0.0005),TPOX的等位基因9(OR=0.65,95%CI=0.47-0.89,p=0.0072),和CSF1PO的等位基因14(OR=0.27,95%CI=0.11-0.68,p=0.0035)。而案例组有一个等位基因频率显著高于对照组:TPOX的等位基因11(OR=1.79,95%CI=1.45-2.22,p<0.0001)。结论 :据我们所知,本项行为遗传学研究首次清楚表明了特定的遗传标记与非精神病罪犯的冲动暴力行为之间的密切关系。进一步的前瞻性工作将需要确定已辨识出的等位基因是否可以被认为是冲动攻击行为的危险因素以及导致这种关系的基本机制。
BACKGROUND: Genetic polymorphisms Short tandem repeats (STRs) analysis is a well-established method for detecting association between genotypes and phenotypes, but it has not previously been used in genetics studies of impulsive aggressive behavior. PURPOSE: To compare 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433 between men with impulsive aggressive behavioral history and male controls without aggressive impulse aggressiveness , vWA, TPOX, D18S51, D5S818 and FGA). Methods: The AmpFlSTR? Identifiler? Kit was used to compare the distribution of alleles at 407 STR loci in 407 impulsive aggressive cases and 415 controls. Results: The average frequency of the following alleles in men with impulsive aggressive behavior was significantly lower than that in controls: allele 10 (OR = 0.29, 95% CI = 0.16-0.52, p <0.0001) for TH01, allele Allele 9 of TPOX (OR = 0.65, 95% CI = 0.47-0.89, p = 0.0072), and the allele of CSF1PO (OR = 0.71, 95% CI = 0.58-0.86, p = 0.0005) 14 (OR = 0.27, 95% CI = 0.11-0.68, p = 0.0035). In the case group, there was a significantly higher frequency of one allele than the control group: TPOX allele 11 (OR = 1.79, 95% CI = 1.45-2.22, p <0.0001). CONCLUSIONS: To the best of our knowledge, this behavioral genetic study for the first time clearly shows the close relationship between a specific genetic marker and the impulsive violence of non-psychiatric criminals. Further forward-looking work will need to determine whether the identified alleles can be considered as risk factors for impulsive aggressive behavior and the underlying mechanism that led to this relationship.