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目的:观察伊立替康联合氟尿嘧啶及亚叶酸钙治疗晚期直肠癌的临床疗效及不良作用。方法:晚期直肠癌患者28例均给予伊立替康+氟尿嘧啶+亚叶酸钙治疗,2周为1个周期,2个周期后评价治疗效果和不良反应。结果:患者均完成2个周期化疗,治疗后完全缓解1例,部分缓解9例,疾病稳定11例,疾病进展7例,有效率35.7%,疾病控制率75.0%。治疗期间发生腹泻9例,中性粒细胞减少6例,急性乙酰胆碱综合征6例,脱发3例,患者均可耐受,对症治疗后缓解。结论:伊立替康联合氟尿嘧啶及亚叶酸钙治疗晚期直肠癌疾病控制率高,不良反应轻,患者耐受性好。
Objective: To observe the clinical efficacy and adverse effects of irinotecan plus fluorouracil and leucovorin in the treatment of advanced rectal cancer. Methods: Twenty-eight patients with advanced colorectal cancer were treated with irinotecan plus fluorouracil plus leucovorin, two weeks for one cycle and two cycles for evaluation of treatment and adverse reactions. Results: All patients completed 2 cycles of chemotherapy. One patient was completely relieved after treatment, 9 patients were partly relieved, 11 patients were stable, 7 patients were advanced. The effective rate was 35.7% and the disease control rate was 75.0%. 9 cases of diarrhea occurred during treatment, neutropenia in 6 cases, 6 cases of acute acetylcholine syndrome, hair loss in 3 cases, patients can tolerate symptomatic relief. CONCLUSION: The combination of irinotecan with fluorouracil and leucovorin in the treatment of advanced rectal cancer has high disease control rate, mild adverse reactions and good patient tolerance.