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提出了以吸附和催化原理灭活病毒的设想 ,旨在开发出对病毒有过滤、吸附及灭活作用的高效非特异性催化材料 ,应用于各种防护设施 ,有效控制非典型肺炎 (SARS)的传播 .采用与SARS病毒相似的副流感病毒作为模拟对象 ,进行了吸附及灭活该病毒的催化材料研究 ,并考察了催化材料对哺乳动物细胞的毒性 .结果表明 ,病毒气溶胶的阻留及吸附结果与基于DNA吸附的色谱分析结果相一致 ;部分材料可以强烈地吸附病毒 ( 10 0 % ) ,甚至在强烈振荡下并洗脱至第 3次 ,病毒也不能脱附 ;一些材料不仅可以吸附病毒 ,而且强烈振荡后的洗脱液虽然表现出一定的血凝效价 ,但接种鸡胚后 ,病毒并不增殖 ,说明材料具有明显的催化病毒灭活性能 ;对细胞毒性极低的材料可以用在与人体接触的防护材料和设施中 .筛选出的性能优异的催化材料 ,拟进一步考察其对SARS病毒的灭活作用
The idea of inactivating viruses by adsorption and catalysis was proposed in order to develop efficient non-specific catalytic materials that can filter, adsorb and inactivate viruses. They are used in various protective facilities to effectively control SARS The parasite virus similar to SARS virus was used as a model to study the adsorption and inactivation of the virus and the toxicity of the catalytic material to mammalian cells.The results showed that the retention of virus aerosol The adsorption results are consistent with the results of the chromatographic analysis based on DNA adsorption; some materials strongly adsorb the virus (100%), and the virus can not desorb even under strong shaking and elution to the third time; some materials can not only adsorb Virus, and the strong shaking after the elution showed some hemagglutination titer, but after inoculation of chicken embryo, the virus does not proliferate, indicating that the material has obvious catalytic activity of the virus inactivation; for very cytotoxic materials can be Used in contact with the human body protective materials and facilities.Screened the excellent performance of the catalytic material, it is intended to further investigate the SARS virus inactivation