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目的探讨河北医科大学第四医院妇科门诊患者人乳头瘤病毒(HPV)感染情况及型别分布情况,为预防HPV感染和宫颈癌防治提供依据。方法采用核酸分子快速导流杂交技术对13 933例妇科门诊患者的宫颈细胞标本进行21种HPV亚型的基因检测,不同年龄组HPV感染率比较采用卡方检验。结果 13933例受检者中,HPV感染5 979例,感染率为42.9%。共计检出21种亚型,9 023例次HPV感染,其中HPV高危型7 823例次占86.7%,感染前三位分别为HPV-16、HPV-52、HPV-58;HPV低危型1 200例次占13.3%,感染前三位分别为HPV-CP8304、HPV-11、HPV-6;17~25岁和≥56岁年龄组HPV感染率相对较高,与其他年龄组比较差异有统计学意义。结论妇科门诊患者HPV感染率较高,且以高危型HPV感染为主,其中最常见的感染亚型是HPV-16、HPV-52、HPV-58。不同年龄组HPV感染率差异有统计学意义,17~25岁和≥56岁年龄组HPV感染率相对较高。
Objective To investigate the prevalence and type distribution of human papillomavirus (HPV) in gynecology outpatient department of the Fourth Hospital of Hebei Medical University and provide evidence for prevention of HPV infection and cervical cancer. Methods A total of 21 types of HPV subtypes were detected in 13 933 cases of gynecological outpatients by rapid flow-through hybridization. The HPV infection rates of different age groups were compared by chi-square test. Results Of 13933 subjects, HPV infection was 5 979 with an infection rate of 42.9%. A total of 21 subtypes and 9 023 HPV infections were detected, of which 7283 were HPV high-risk cases, accounting for 86.7%. The top three were HPV-16, HPV-52 and HPV-58, respectively. 200 cases accounted for 13.3%, the first three were HPV-CP8304, HPV-11, HPV-6 respectively; HPV infection rate was relatively high in 17-25 years old and ≥56 years old group, statistically significant compared with other age groups Significance of learning. Conclusions The prevalence of HPV infection in gynecology outpatients is high, and most of them are high-risk HPV infections. The most common infection subtypes are HPV-16, HPV-52 and HPV-58. HPV infection rates in different age groups were statistically significant, 17 to 25 years old and ≥ 56 years old group HPV infection rate is relatively high.