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本文介绍了用氚照射处于不同细胞周期的离体淋巴细胞所诱发的染色体畸变的剂量-效应关系。实验表明:~3H-TdR 或 HTO 照射 S 期,G_2期淋巴细胞诱发染色体单体型畸变;染色单体断裂与剂量呈线性关系,但~3H-TdR 每拉德诱发的每个细胞中的染色单体断裂产额约是 HTO 的10倍。HTO 照射 Go 期淋巴细胞诱发染色体型畸变。HTO 诱发双着丝点体加着丝点环与剂量的关系,适宜以 Y=αD+βD_2表示。以~(60)Co-γ射线为参考辐射,HTO 诱发人淋巴细胞双着丝点体加着丝点环的 RBE 值,在本实验用的剂量率和剂量范围内不是恒定的,而是随β射线剂量的增加而降低,其波动范围在2.6—1.4之间。
This article describes the dose-response relationship of chromosomal aberrations induced by isolated lymphocytes at various cell cycles irradiated with tritium. Experiments show that: ~ 3H-TdR or HTO irradiated S phase, G2 phase lymphocyte induced chromosome haplotype distortion; chromatid fragmentation and dose was linear, but ~ 3H-TdR per Radian induced per cell staining Monomer fracture yield is about 10 times that of HTO. HTO irradiation Go lymphocytes induced chromosome aberrations. HTO-induced doubanuors plus point ring ring and dose relationship, suitable for Y = αD + βD_2 said. Using ~ (60) Co-γ-ray as a reference radiation, HTO induces RBE values of human lymphocyte bipartite dots plus centromeric rings, which are not constant at the dose rates and dose ranges used in this experiment, β-ray dose decreases and its fluctuation range between 2.6-1.4.