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目的探讨~(13)C-嘧塞西啶呼气试验与慢性肝病患者肝脏储备功能的关系。方法将40例各种肝病患者分为慢性肝炎组和肝硬化组,每组20例；按病因分为酒精性肝病组(16例)和病毒性肝病组(24例)；另选10例健康者为对照组；均做血生化、肝功能检测及~(13)C-嘧塞西啶呼气试验。结果在对照组(肝功能正常组),慢性肝炎组和肝硬化组的诸项指标中,血清白蛋白(ALB)、前白蛋白(PreALB)水平逐渐下降：总胆红素(TBIL)、直接胆红素(DBIL)、总胆汁酸(TBA)、凝血酶原时间(PT)、凝血酶原时间的国际标准化比值(INR)及终末期肝病模型评分(MELD)逐渐升高,~(13)C-嘧塞西啶呼气试验丰度(CUM30,CUM120,MVmax30)水平逐渐下降并且有显著性差异。按病因分组,酒精性肝病组和病毒性肝病组的以上数据无显著性差异。结论~(13)C-嘧塞西啶呼吸试验是评价肝病患者肝脏功能的安全有效的诊断工具。
Objective To investigate the relationship between ~ (13) C-methicillin-resistant breath test and hepatic reserve function in patients with chronic liver disease. Methods Forty patients with various liver diseases were divided into chronic hepatitis group and cirrhosis group, with 20 cases in each group. According to cause, alcoholic liver disease group (n = 16) and viral liver disease group (n = 24) As control group; blood biochemistry, liver function tests and ~ (13) C-pyrazinamide breath test. Results Serum albumin (ALB) and prealbumin (PreALB) were gradually decreased in the control group (normal liver function group), chronic hepatitis group and cirrhosis group. Total bilirubin (TBIL), direct The levels of BIL, TBA, PT, INR and MELD increased gradually, C-methicillin breath test Abundance (CUM30, CUM120, MVmax30) levels gradually decreased and there was a significant difference. According to the cause of grouping, alcoholic liver disease group and viral liver disease group of the above data no significant difference. Conclusion ~ (13) C-pyrazinamide breath test is a safe and effective diagnostic tool to evaluate liver function in patients with liver disease.