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细胞内游离钙是介导细胞生理和病理作用的重要信使，其浓度异常升高会引起细胞的急慢性损伤和死亡；同时也造成肾血液动力学改变，导致肾小球细胞增生、肥大，促进肾脏病的慢性进展。钙拮抗剂不仅降低全身血压，还抑制肾实质细胞增生、调节系膜处理大分子物，清除和减少自由基产生，降低残存肾代谢，减轻肾钙化。因此，钙拮抗剂已用于防治缺血、某些药物引发的肾损伤，延缓慢性肾功能不全的进展，减少移植肾排斥反应等。
Intracellular free calcium is an important messenger that mediates cell physiology and pathology. Abnormal increase of its concentration will cause acute and chronic cell injury and death. At the same time, it also causes changes of renal hemodynamics, resulting in glomerular cell proliferation, hypertrophy, Chronic kidney disease progression. Calcium antagonists not only reduce systemic blood pressure, also inhibit renal parenchymal cell proliferation, regulating mesangial treatment of macromolecules, clearance and reduce free radical production, reduce residual renal metabolism, reduce renal calcification. Therefore, calcium antagonists have been used to prevent ischemia, renal damage caused by certain drugs, delay the progression of chronic renal insufficiency, reduce renal allograft rejection and so on.