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目的 为在扩大的人群中验证和推广河南林县河顺乡“七五”攻关成果 ,自1 992年在食管癌高发区河北省磁县 9个乡 ,进行食管癌前病变的药物阻断治疗研究。方法 通过 40～ 6 5岁人群的食管细胞学普查 ,检出食管重增 3990例 ,轻增 5 34 6例 ,随机分为治疗组和对照组。重增和轻增治疗组分别服用中药增生平片和核黄素钙片 ,对照组均服用安慰剂。服药 3年后食管细胞学复查。结果 重增治疗组癌变相对危险度( RR) =0 .5 0 ,95 % CI=0 .33～ 0 .75 ,抑癌率 49.9% ;同时根据细胞学五级六类分级标准计算整体疗效 ,以对照组为标准组 ,其 Ridit=0 .5 8,95 % CI=0 .5 6～ 0 .6 0。轻增组的结果分别为 Ridit=0 .5 9,95 % CI=0 .5 7～ 0 .6 1 ;RR=0 .80 ,95 % CI=0 .5 2～ 1 .2 2 ,抑癌率 2 0 .4%。结论 本次结果与河南省林县大人群的阻断结果一致 ,表明增生平阻断食管癌前病变、预防食管癌的效果是肯定的。整体疗效显示 ,轻增人群服用核黄素钙片也有一定的潜在效果。
The purpose was to verify and promote the results of the “Q5” research in Heshun Township, Lin County, Henan Province, and to conduct drug blockade for esophageal precancerous lesions in nine townships in Ci County, Hebei Province, a high-risk area of esophageal cancer in 1992. the study. Methods A total of 3990 cases of esophageal reinduction and 5 346 cases of slight increase in esophageal cancer were detected by esophageal cytology from 40 to 65 years old. They were randomly divided into treatment group and control group. The patients in the re-growth and light increase treatment groups were treated with TCM and riboflavin, respectively, while the control group received placebo. After 3 years of esophageal cytology review. Results The relative risk of recurrence of cancer in the treatment group (RR) = 0.50, 95% CI = 0.33 - 0.75, and the tumor suppressor rate was 49.9%; the overall efficacy was calculated according to the cytological grade 5 and 6 criteria. The control group was used as the standard group with Ridit=0.5 8, 95% CI=0.56 to 0.60. The results of the light increase group were: Ridit=0.95, 95% CI=0.57 to 0.61; RR=0.80, 95% CI=0.52-2.1.2, and cancer suppression. The rate is 20.4%. Conclusion The results are consistent with the blockade results of large population in Lin County, Henan Province, indicating that hyperplasia has positive effects on blocking esophageal precancerous lesions and preventing esophageal cancer. The overall efficacy shows that lightly increasing the use of riboflavin calcium tablets also has a certain potential effect.