【摘 要】
:
Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article
【机 构】
:
Edmond H. Fischer Signal Transduction Laboratory,China-Japan Union Hospital,The Key Laboratory of Pa
【基金项目】
:
Open Foundation of State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University
论文部分内容阅读
Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.
其他文献
In this article the concept of local conjugation of a C1 mapping between two Banach manifolds is introduced. Then a rank theorem for nonlinear semi-Fredholm ope
Hierarchical art was used to solve the mixed mode placement for three dimensional (3-D) inte-grated circuit design. The 3-D placement flow stream includes hiera
A novel bisupported bimetal catalyst PVP-PdCl2-FeSO4/Al-Mont-PEG600 was prepared by immobilization of PVP (poly (N-vinyl-2-pyrrolidone)) supported bimetallic ca
The title compound, C24H28ClCuN4O6 (Mr = 567.49), has been prepared and its crystal structure has been determined by X-ray diffraction method. The crystal belon
Novel water-soluble prodrugs of combretastatin A-4 (5-8) were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5,
We compile a sample of 11 Fanaroff-Riley type Ⅰ Radio Galaxies (FR-ⅠRGs) with multi-wavelength observations to address the dynamic behavior of jets in these o
The title compound C18H16N4O3 (Mr = 336.35) has been synthesized and characte- rized by elemental analysis and single-crystal X-ray diffraction. The Schiff base
This paper employs the integral-averaged method of thickness to approximate the periodical flows in a piezoelectric micropump, with a shallow water equation inc
The non-covalent complexes between lappaconitine (LA) and β-cyclodextrin (β-CD) have been detected and characterized by electrospray ionization combined with
Two large-pore metal-doped aluminophosphates, Mn4Al5(PO4)12[N(C2H4NH3)3]3[N(C2H4NH3)2·(C2H4NH2)](NH4)2·14H2O(Mn4-NJU) and Co4Al5(PO4)12[N(C2H4NH3)3][N(C2H4NH3