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目的 观察精纯抗栓酶治疗急性脑梗死的临床疗效。 方法 1 56例经临床和头颅 CT确诊的急性脑梗死患者 ,随机分为治疗组 (80例 )和对照组 (76例 )。对照组应用低分子右旋糖酐 50 0 ml加复方丹参 2 0 ml静滴 ,每天 1次 ,连用 1 4天。治疗组在对照组治疗基础上 ,辅予应用精纯抗栓酶。两组均于治疗前后观察血液流变学、血小板计数及出、凝血时间。并于治疗前和治疗后 2 1天作神经功能评分 ,结合治疗后患者病残程度评定疗效。 结果 治疗组有效率 88.8% ,明显高于对照组 68.4 % (P <0 .0 1 ) ,治疗组治疗后纤维蛋白原下降明显 (P <0 .0 0 1 ) ,部分患者凝血时间延长 ,对出血时间及血小板无明显影响。 结论 精纯抗栓酶能有效地降低纤维蛋白原 ,降低血粘度促进纤溶过程 ,是急性脑梗死早期治疗安全、有效的药物
Objective To observe the clinical efficacy of antithrombotic enzyme in the treatment of acute cerebral infarction. Methods Fifty-six patients with acute cerebral infarction diagnosed by clinical and cranial CT were randomly divided into treatment group (n = 80) and control group (n = 76). The control group of low molecular weight dextran 50 0 ml compound Danshen 20 ml intravenous infusion once a day, once every 14 days. Treatment group in the control group based on the treatment, supplemented by the application of pure antithrombotic enzyme. Both groups were observed before and after treatment of hemorheology, platelet count and out, clotting time. And before treatment and 21 days after treatment for neurological function score, combined with the treatment of patients with disabilities after the assessment of efficacy. Results The effective rate of the treatment group was 88.8%, which was significantly higher than that of the control group (68.4%, P <0.01). The fibrinogen of the treatment group decreased significantly (P <0.01), and the clotting time of some patients was longer. Bleeding time and no significant effect of platelets. Conclusions The pure antithrombotic enzyme can effectively reduce fibrinogen, reduce blood viscosity and promote fibrinolytic process, which is safe and effective for the early treatment of acute cerebral infarction