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一种新颖微机处理控制的轻便输液泵(Pancretec Provider IV 2000~(TM)),用于癌症病人的体内外试验,其流速可达每小时0.2～83ml,能在200小时(8.3天)内输送液体1～1999ml。该泵可进行间隙输液和连续输液两种程序。大量临床研究表明,这种泵能够输送麻醉止痛药、抗凝剂、胰岛素、抗生素和某些激素,以便延长在非卧床病人中的药物释放。本文报道该输液系统体内外控释研究的结果。体外实验是在标准室温和压力下进行,通过重量分析和容量分析法在50ml的圆锥形塑料试管中测定输液流速。为了考核输送
A novel microcomputer-controlled, lightweight infusion pump (Pancretec Provider IV 2000 ™) for the in vitro and in vivo testing of cancer patients at a flow rate of 0.2 to 83 ml per hour delivers in 200 hours (8.3 days) Liquid 1 ~ 1999ml. The pump can be intermittent infusion and continuous infusion of two programs. Numerous clinical studies have shown that this pump is capable of delivering narcotic painkillers, anticoagulants, insulin, antibiotics and certain hormones in order to prolong drug release in ambulatory patients. This paper reports the results of in vitro and in vivo controlled release studies of this infusion system. In vitro experiments were performed at standard room temperature and pressure. Infusion flow rates were determined gravimetrically and volumetrically in 50 ml conical plastic tubes. In order to assess the delivery