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目的:观察急性毒鼠强中毒患者心肌酶的变化及其临床意义。方法:动态观察155例急性毒鼠强中毒患者的临床表现、心肌酶活力、心电图,使用SPSS12.0统计软件进行统计学处理。结果:155例急性毒鼠强中毒患者。实验室检查发现:天冬氨酸转氨酶、肌酸磷酸激酶、乳酸脱氢酶、肌酸激酶同功酶、ECG异常率分别为81.8%、90.9%、73.2%、77.5%、51.7%。心肌酶均值第1天升高,第2～4天达到最高峰,出现1～6d的峰值平台期后恢复正常。轻、中、重度中毒患者心肌酶活力的各时点对应比较,差异有统计学意义(P<0.01)。抽搐越重,酶活力越高,升高持续时间越长,ECG异常率越高。结论:毒鼠强中毒患者血清心肌酶升高由骨骼肌、心肌等组织损伤引起,这种损伤是可逆的。血清心肌酶水平可以作为反映病情的重要指标之一。
Objective: To observe the changes of myocardial enzymes in patients with acute tetramine poisoning and its clinical significance. Methods: The clinical manifestations, myocardial enzyme activity and electrocardiogram of 155 acute poisoning rats were observed dynamically. The data were analyzed by SPSS12.0 statistical software. Results: 155 cases of acute tetramine poisoning patients. Laboratory tests showed that aspartate aminotransferase, creatine phosphokinase, lactate dehydrogenase, creatine kinase isoenzyme, and ECG were 81.8%, 90.9%, 73.2%, 77.5% and 51.7% respectively. The mean value of myocardial enzyme increased on the first day, peaked on the second to the fourth day, and returned to normal after a peak period of 1 ~ 6 days. Light, moderate and severe poisoning in patients with myocardial enzyme activity at each time point correspondence, the difference was statistically significant (P <0.01). The heavier twitch, the higher the enzyme activity, the longer the duration of the increase, the higher the rate of abnormal ECG. Conclusion: The increase of serum myocardial enzymes in patients with tetramine poisoning is caused by tissue damage such as skeletal muscle and myocardium, which is reversible. Serum myocardial enzyme levels can be used as one of the important indicators to reflect the disease.