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目的:研究慢性乙型肝炎病毒(HBV)感染后在不同临床阶段的乙肝表面抗原(HBs Ag)的定量值变化。方法:选取2013年3月到2014年7月我院收治的254例未经抗病毒治疗的HBV感染患者为研究对象,根据患者病情的不同,分为慢性HBV携带者(A组)46例,慢性乙型肝炎者(B组)97例,乙肝肝硬化者(C组)73例,原发性肝癌(D组)38例。定量检测所有患者血清HBs Ag水平,并对检测结果进行统计、分析。结果:1从四组患者的HBs Ag定量值来看,从高到低分别为A组、B组、C组、D组;2HBs Ag与年龄呈负相关性(rs=-0.482,P=0.000)。结论:随着患者感染时间的延长,其体内的HBs Ag定量值逐渐下降,HBs Ag定量与患者年龄呈负相关性。
Objective: To study the quantitative changes of hepatitis B surface antigen (HBs Ag) in different clinical stages after chronic hepatitis B virus infection. Methods: A total of 254 HBV-infected patients without antiviral therapy admitted to our hospital from March 2013 to July 2014 were selected as the study subjects. According to the patient’s condition, 46 cases were divided into chronic HBV carriers (group A) 97 cases of chronic hepatitis B (group B), 73 cases of hepatitis B cirrhosis (group C) and 38 cases of primary liver cancer (group D). Quantitative detection of serum HBsAg levels in all patients, and the test results were statistically analyzed. From the four groups of patients HBsAg quantitative values, from high to low were A group, B group, C group, D group; 2HBs Ag and age was negatively correlated (rs = -0.482, P = 0.000 ). Conclusion: With the prolongation of infection time, the quantitative value of HBsAg gradually decreases, and the quantitative analysis of HBsAg has a negative correlation with the patient’s age.