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罗非昔布(Rofecoxib,商品名Vioxx)为新的特异性Ⅱ型环氧化酶(COX—2)抑制剂,由美国Merck Sharp＆Dohme公司开发,于 1999年 6月首次在墨西哥上市,同年7月在美国和英国上市。罗非昔布化学名为4-[4’-(甲磺酰基)苯基〕-3-苯基-2(5H)-呋喃酮。结构式如下:
Rofecoxib (brand name Vioxx), a new type II cyclooxygenase (COX-2) inhibitor, was developed by Merck Sharp & Dohme in the United States and was first marketed in Mexico in June 1999. In July of the same year, Listed in the United States and the United Kingdom. The chemical name of rofecoxib is 4- [4 ’- (methylsulfonyl) phenyl] -3-phenyl-2 (5H) -furanone. Structural formula is as follows: