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目的探讨胰腺腺鳞癌的生物学特征及临床治疗方法。方法回顾性分析我院 1995年-2005年间收治的6例胰腺腺鳞癌的临床特点、影像学改变、病理学特征、治疗过程及随访资料并结合文献讨论。结果本组6例胰腺腺鳞癌患者．平均年龄(51．8±10．8)岁。肿瘤位于胰头 4例,胰体尾1例,胰尾1例。行胰头十二指肠切除3例,其中一例因为肿瘤侵犯门静脉行门静脉切除、人造血管重建术。行胰体尾切除、脾切除术1例。1例胰头肿块术中发现肿瘤广泛浸润,行胰腺肿块活检和空肠造瘘术。1例肿瘤已侵犯胃底,行胰体尾、脾脏切除合并部分胃切除。病理检查:瘤体平均5．2 cm×4．1 cm×3．0 cm,肿瘤原发灶和肝转移灶均呈腺癌和鳞癌混杂表现。肿瘤呈浸润生长的特点。4例胰头肿瘤中侵犯十二指肠、胆总管3例,侵犯包绕门静脉1例。肿瘤侵犯神经4例,淋巴结转移3例。随访6例,死亡4例术后生存6-8个月,平均生存6．7个月,均死于肿瘤复发和肝转移。结论胰腺腺鳞癌以腺癌和鳞癌混合为组织学特点,恶性程度高,预后差。
Objective To investigate the biological characteristics and clinical treatment of pancreatic adenosquamous carcinoma. Methods The clinical features, imaging changes, pathological features, course of treatment and follow-up of 6 cases of adenosquamous pancreatic adenocarcinoma admitted to our hospital from 1995 to 2005 were analyzed retrospectively. Results The group of 6 patients with pancreatic adenosquamous carcinoma. The average age (51.8 ± 10.8) years old. The tumor was located in the pancreas in 4 cases, 1 case of pancreatic body tail, 1 case of pancreatic tail. Three cases of pancreaticoduodenectomy, one case because of tumor invasion of the portal vein portal vein resection, artificial vascular reconstruction. A pancreatic body tail resection, splenectomy in 1 case. One case of pancreatic head mass found extensive tumor invasion, pancreatic mass biopsy and jejunostomy. One case had tumor invasion of the fundus, pancreatic body tail, splenectomy combined with partial gastrectomy. Pathological examination: The average tumor size was 5.2 cm × 4.1 cm × 3.0 cm. The primary and metastatic tumors showed mixed appearance of adenocarcinoma and squamous cell carcinoma. Tumor was infiltrative growth characteristics. 4 cases of pancreatic head tumor invaded the duodenum, common bile duct in 3 cases, 1 case of infiltration around the portal vein. Tumor invasion of nerve in 4 cases, 3 cases of lymph node metastasis. Follow-up 6 cases, 4 died of postoperative survival 6-8 months, the average survival of 6.7 months, died of tumor recurrence and liver metastases. Conclusions Pancreatic adenosquamous carcinoma is characterized by the combination of adenocarcinoma and squamous cell carcinoma with high malignant degree and poor prognosis.