论文部分内容阅读
整合素是一类异二聚体家族,作为细胞外基质(extracellular matrix,ECM)的受体,选择性表达于激活的内皮细胞的有腔和无腔表面,参与内皮细胞的移行、增生、分化和毛细血管样管腔结构的形成,并最终形成新生血管。在脉络膜新生血管形成过程中,整合素与多种细胞因子如碱性成纤维细胞生长因子、血管内皮生长因子、血小板衍生生长因子等,以及基质金属蛋白酶协同作用,介导细胞向细胞间和ECM的移行和黏附,并调控细胞周期。整合素及其ECM配体的结合引发一系列复杂的胞内级联信号,包括黏着斑激酶的酪氨酸磷酸化、细胞内钙离子水平增加、细胞周期蛋白合成以及早期基因表达等;阻断整合素及其配体的作用能抑制细胞生长或诱导细胞凋亡。已有的研究结果提示,整合素可能是未来治疗脉络膜新生血管的有效靶点之一。
Integrins are a family of heterodimers that act as receptors for the extracellular matrix (ECM) and are selectively expressed on the luminal and non-luminal surfaces of activated endothelial cells and are involved in the migration, proliferation and differentiation of endothelial cells And capillary-like lumen structure formation, and eventually the formation of new blood vessels. In the process of choroidal neovascularization, integrins and a variety of cytokines such as basic fibroblast growth factor, vascular endothelial growth factor, platelet-derived growth factor, and matrix metalloproteinases synergistically mediate the intercellular and ECM The migration and adhesion, and regulation of cell cycle. The combination of integrins and their ECM ligands triggers a series of complex intracellular cascades including tyrosine phosphorylation of focal adhesion kinase, increased levels of intracellular calcium, cyclin synthesis, and early gene expression; blocking The role of integrins and their ligands can inhibit cell growth or induce apoptosis. The existing results suggest that integrins may be one of the effective targets for the treatment of choroidal neovascularization in the future.