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耐药伤寒的临床症状重,热程长、并发症多、治疗困难.1990年重庆医科大学附一院传染科肖永红医师等对四川达县流行的42例耐药伤寒(均经血或骨髓培养、药敏试验证实),分别用四种氟喳诺酮类药物及对照组进行治疗,其方法与结果如下:病人随机分为五组,第一组8例,日服氟哌酸0.2～0.4g,日三次,共14天,治愈率为25%;第二组7例,日服甲氟哌酸0.4g.日二次,共14天,治愈率为83.3%;第三组10例,口服氟嗪酸0.3g,日三次,共14天,治愈率为100%;第四组8例,口服环丙氟哌酸0.4～0.5g,日二次,共14天,治愈率为87.5%:对照组9例,静脉滴注氨苯春霉素,5～6g/d,并加用庆大霉素16～24万u/d静滴或肌注,共14～21天,治愈率为33.3%.
Clinical symptoms of drug-resistant typhoid fever, long heat stroke, complications, treatment difficulties .1990 Chongqing Medical University Hospital of Infectious Diseases Dr. Xiao Yonghong and other epidemic of 42 cases of Dachang, Sichuan resistant typhoid fever (both menstrual blood or bone marrow culture, Drug susceptibility test confirmed) were treated with four fluoroquinolones and the control group, the methods and results are as follows: The patients were randomly divided into five groups, the first group of 8 patients, daily norfloxacin 0.2 ~ 0.4g , Three times a day, a total of 14 days, the cure rate was 25%; the second group of 7 cases, the day of norfloxacin 0.4g. The second day, a total of 14 days, the cure rate was 83.3%; the third group of 10 cases, oral The third group of 8 cases, oral ciprofloxacin 0.4 ~ 0.5g, two times a day for a total of 14 days, the cure rate was 87.5%: three days, a total of 14 days, the cure rate was 100% Control group, 9 cases, intravenous infusion of amilorubicin, 5 ~ 6g / d, and add gentamicin 16 ~ 240,000 u / d intravenous infusion or intramuscular injection, a total of 14 to 21 days, the cure rate was 33.3 %.