本文讨论了靶向慢性感染细胞的抗病毒战略,重点是 HIV 蛋白酶抑制剂。HIV-1蛋白酶抑制剂可干扰病毒生活周期后期的功能。蛋白酶抑制剂可通过阻断细胞内聚合蛋白的加工(导致非感染病毒毒粒的生长),从而阻止了感染的传播。sCD4-KDEL 诱变蛋白则从茅生毒粒表面清除病毒包膜蛋白,以阻止病毒在慢性感染细胞中的传播,而单克隆抗体-毒素或 sCD4毒素共轭蛋白可靶向并杀死感染的细胞。 This article discusses antiviral strategies that target chronically infected cells, with an emphasis on HIV protease inhibitors. HIV-1 protease inhibitors can interfere with later life cycles of the virus. Protease inhibitors prevent the spread of infection by blocking the processing of intracellular polyproteins (leading to the growth of non-infected virus virions). The sCD4-KDEL mutagen cleans the viral envelope protein from the surface of Maitis to block transmission of the virus in chronically infected cells, whereas the monoclonal antibody-toxin or sCD4 toxin conjugated protein targets and kills the infected cell.