氟康唑是三唑类第3代抗真菌药,对真菌的细胞色素P450依赖酶具有高度特异性,能强力而特异地抑制真菌细胞膜的麦角甾醇的合成,使真菌细胞膜缺损,通透性增加,从而抑制真菌生长或使真菌死亡。目前有文献报道氟康唑用于预防和治疗各种真菌感染时有不良反应发生,本例报道静滴氟康唑致严重肝功能损害1例。患者,女,81岁,主因“发现白细胞减少4月”入院。诊断:Felty综合征、粒细胞缺乏症、慢性喘息型支气管炎合并感 Fluconazole is a triazole third-generation antifungal agent that is highly specific to fungal cytochrome P450-dependent enzymes and potently and specifically inhibits the synthesis of ergosterol in the fungal cell membrane and increases fungal cell membrane defects and permeability , Thereby inhibiting fungal growth or fungal death. Currently there are reports of fluconazole used in the prevention and treatment of various fungal infections have adverse reactions, this case reports of intravenous infusion of fluconazole caused severe liver damage in 1 case. Patient, female, 81 years old, mainly due to “found leukopenia in April” admitted. Diagnosis: Felty syndrome, agranulocytosis, chronic asthmatic bronchitis with flu