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目的:探讨抗苗勒管激素(AMH)联合性激素诊断多囊卵巢综合征(PCOS)的临床价值及在年龄分层中的意义。方法:选取临汾市中心医院2015年1月至2018年12月收治的PCOS患者164例(PCOS组)和体检健康女性120例(对照组)的临床资料，比较两组年龄、性激素指标及AMH水平，分析单一指标和联合检测诊断PCOS临床效能，同时评价AMH水平与年龄、性激素指标间相关性，观察年龄分层对PCOS诊断的影响。结果:PCOS组血清AMH、睾酮(T)、黄体生成素(LH)及LH/卵泡刺激素(FSH)比值分别为(62.90±5.19)pmol/L、(1.36±0.55)nmol/L、(12.86±2.4)IU/L、(2.27±0.86)，均显著高于对照组的(27.22±3.72)pmol/L、(0.87±0.30)nmol/L、(6.41±1.18)IU/L、(1.15±0.53)(n t＝7.38、3.76、5.15、3.89，均n P0.05)；AMH诊断PCOS曲线下面积(AUC)为0.846，均显著高于T、LH、LH/FSH比值的0.714、0.765、0.783(n Z＝2.09、2.43、2.20，均n P0.05). The AUC of AMH in diagnosis of PCOS was 0.86, which was significantly higher than T, LH and LH/FSH(0.714, 0.765, 0.783)(n Z=2.09, 2.43, 2.20, all n P<0.05). Spearman correlation analysis showed that there was positive correlation between AMH level and T, LH, LH/FSH in PCOS group (n r=0.27, 0.25, 0.33, all n P0.05). The critical value of AMH in diagnosis of PCOS was decreased with the increase of age.The sensitivity, specificity and ROC-AUC of AMH in 25-29 years old group and 30-37 years old group were higher than whole population(n r=-0.33, n P<0.05).n Conclusion:The combination of AMH+ T, AMH+ LH or AMH+ T+ LH can improve the diagnosis sensitivity of PCOS, but the specificity is similar to AMH alone; then age stratification for the AMH critical value can increase the diagnosis accuracy of PCOS.