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本文研究了模拟克山病病区易感人群膳食组成的饲料及在这种饲料中补充钙和硒对大鼠生长、代谢的影响。结果表明,模拟病区膳食的饲料中除低硒外低钙特别突出,所饲大鼠血清钙水平及全血GSH-Px酶活性明显低于常规饲料组;大鼠的生长状态、血清总蛋白及血清和心肌几种酶(GOT,GPT,LDH,α-HBDH,CK)活性均偏离常规饲料组。在模拟病区膳食的饲料中单纯补充钙可明显改善大鼠的生长状态和酶活性的偏移,呈规律性趋向常规饲料组。表明低钙在喂养病区膳食的大鼠所造成的生长迟缓、代谢偏移中起重要作用。补充钙同时补充硒效果更好。结合流行病学资料表明在低硒环境下合并有明显的低钙,可引起克山病发病。
In this paper, we studied the diets that simulate the diet of susceptible population in Keshan disease area and the effects of calcium and selenium supplementation on the growth and metabolism of rats. The results showed that in addition to low selenium and extra-low calcium, the levels of serum calcium and GSH-Px in rats fed with simulated ward diet were significantly lower than those in the normal diet. The growth status, serum total protein (GOT, GPT, LDH, α-HBDH, CK) in serum and myocardium all deviated from the normal diet group. Supplementation of calcium in the diet simulating ward diet can obviously improve the migration of rat’s growth state and enzyme activity, showing regularity toward the conventional feed group. This indicates that hypocalcemia plays an important role in the growth retardation and metabolic imbalance in rats fed the ward diet. Calcium supplementation while adding selenium better. Combined with epidemiological data show that low selenium in combination with significant low calcium can cause Keshan disease.