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作者研究“不可逆”性通气阻塞病人不同茶碱血浆浓度时通气、血液动力和主观感觉。10例病人男性,49～68岁,有长期吸烟史,数年来曾用各种支气管扩张药治疗。按照随机双盲交叉试验设计,给予下列治疗:①口服脱水茶碱小剂量,低血浆浓度9.0～12.5μg/ml;②口服脱水茶碱大剂量,高血浆浓度17～22μg/ml;③安慰剂。结果发现上述各种治疗的肺功能有显著差异(p<0.05)。第1秒最大呼气量(FEV_1)大剂量茶碱比安慰剂最大的平均值增加21.3%,小剂量比安慰剂增加6.0%。同样,
The authors studied the “irreversible” ventilation in patients with different theophylline plasma concentrations of ventilation, hemodynamic and subjective perception. Ten patients were male, 49 to 68 years old, with a long history of smoking and had been treated with various bronchodilators over the years. According to a randomized, double-blind crossover design, the following treatments were given: (1) low dose oral dehydrated theophylline, low plasma concentration 9.0 ~ 12.5μg / ml; ② oral dehydrated theophylline high dose, high plasma concentration 17 ~ 22μg / ml; ③ placebo . The results showed significant differences in lung function (p <0.05) among the above treatments. Maximum expiratory volume in 1 second (FEV_1) The high-dose high-dose theophylline increased by 21.3% over the maximum mean of placebo and 6.0% at a lower dose than placebo. same,