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报告了对不同纬度病区的内蒙呼盟布达哈旗(北纬48°,海拨500-600m,年均气温5-8℃)和陕西省永寿县(北纬34.5°,海拔1000-1450m,年均气温8 10℃)大骨节病患儿,在不同季节进行分析研究的结果。和国内其他病区同样,大骨节病患儿及病区人群红细胞的硒含量及谷胱甘肽过氧化物酶活性,均在低水平。但病儿红细胞的膜脂组成则有别于病区对照,即使两个纬度不同的病区均可见患儿的磷脂,尤其磷脂酰胆碱含量降低,不饱和脂酸相对减少,脂质过氧化产物增加。出现胆固醇/磷脂,鞘磷脂/磷脂酰胆碱,饱和脂酸/不饱和脂酸分子比增高的膜老化性改变,并以冬春季变化明显,与本病的发病季节一致,结果表明病儿的膜系统存在异常,抗氧化能力和气温驯化性降低。文中对病区环境低温低硒及长期偏食三因素的病因及发病学意义进行了讨论。
Reported on the Hu’nan Budaha Banner in Inner Mongolia at different latitudes (latitude 48 ° north, altitude 500-600 m, average annual temperature 5-8 ° C) and Yongshou County, Shaanxi Province (latitude 34.5 ° north, elevation 1000-1450 m, year Average temperature 8 10 ℃) children with Kashin-Beck disease, the results of the analysis in different seasons. As with other wards in China, selenium content and glutathione peroxidase activity of erythrocytes in children with Kashin-Beck disease and in the ward are at a low level. However, the composition of membrane lipid in diseased children’s erythrocytes is different from that in the ward, even though the phospholipids in two wards of different latitudes can be seen. In particular, the content of phosphatidylcholine is reduced, the relative content of unsaturated fatty acids is decreased, and the lipid peroxidation Product increased. Occurrence of cholesterol / phospholipid, sphingomyelin / phosphatidylcholine, saturated fatty acid / unsaturated fatty acid increased membrane aging changes, and changes in winter and spring significantly, consistent with the onset of the disease season, the results show that sick children Membrane system is abnormal, anti-oxidation ability and temperature domestication decreased. The essay discusses the etiology and pathogenetic significance of three factors of low temperature, low selenium and long-term partial eclipse in ward environment.