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目的:观察分析多烯磷脂酰胆碱注射液在妊娠期肝内胆汁淤积症(ICP)治疗中的临床价值。方法:选取乐山市五通桥区人民医院2012年2月-2014年9月所收治的100例ICP患者,随机分为两组,每组50例。对照组采用腺苷蛋氨酸,观察组采用腺苷蛋氨酸联合多烯磷脂酰胆碱注射液进行治疗。疗程均为2周,对比两组疗效。结果:两组治疗后瘙痒症状均得到缓解,组间比较,差异无统计学意义(P>0.05)。两组疗后血生化指标均有所下降,观察组下降程度大于对照组,组间比较,差异具有统计学意义(P<0.05)。结论:多烯磷脂酰胆碱注射液可缓解ICP患者瘙痒症状,明显改善其血生化指标。
Objective: To observe the clinical value of polyene phosphatidylcholine injection in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods: 100 ICP patients admitted from February 2012 to September 2014 in People’s Hospital of Wutongqiao District, Leshan were randomly divided into two groups (50 in each group). The control group was treated with adenosylmethionine, and the observation group was treated with adenosylmethionine and polyene phosphatidylcholine injection. The course of treatment was 2 weeks, the two groups were compared. Results: The pruritus symptoms were relieved in both groups. There was no significant difference between the two groups (P> 0.05). The blood biochemical indexes decreased after treatment in both groups, and the degree of decline in the observation group was greater than that in the control group. The differences between the two groups were statistically significant (P <0.05). CONCLUSION: Polyene phosphatidylcholine injection can relieve pruritus symptoms in ICP patients and significantly improve blood biochemical markers.