目的初步探讨９９ｍＴｃ甲氧基异丁基异腈（ＭＩＢＩ）断层显像用于肺癌ｐ糖蛋白（ｐＧＰ）定性检测的可行性。方法采用二时相断层显像，以横断面病灶处９９ｍＴｃＭＩＢＩ的储留指数（ＲＩ）为ｐＧＰ定性指标，以ＲＩ＜０为ｐＧＰ阳性的界值进行ｐＧＰ定性。按ＷＨＯ推荐的分级标准将疗效分为完全或部分缓解（ＣＲ或ＰＲ）及无效（ＮＲ）两组，然后将ｐＧＰ定性结果与疗效进行比较。结果７１例Ⅲ～Ⅳ期肺癌患者原发灶中３５个病灶为ｐＧＰ阳性，其中２９个疗效为ＮＲ，阳性符合率为８２９％；另３６个病灶为ｐＧＰ阴性，其中疗效为ＣＲ（ＰＲ）者２４例，阴性符合率为６６７％。与免疫组化法和ＰＣＲ技术相比，可避免取材受限及ｐＧＰ非均一表达等因素影响。结论９９ｍＴｃＭＩＢＩ断层显像可作为ｐＧＰ定性检查的一个有效补充手段 Objective To investigate the feasibility of 99mTc-methoxyisobutylisonitrile (MIBI) tomography for the qualitative detection of pglycoprotein (pGP) in lung cancer. Methods Two-phase tomography was used. The retention index (RI) of 99mTc-MIBI in the cross-sectional lesions was used as a p-GP qualitative indicator. RI<0 was used as the p-GP positive threshold to perform p-GP qualitative analysis. According to the grading standards recommended by WHO, the efficacy was divided into complete or partial remission (CR or PR) and ineffective (NR) groups, and then the p-GP qualitative results were compared with the efficacy. Results Of the 71 patients with stage III-IV lung cancer, 35 lesions were found to be p-GP positive, of which 29 were NR, and the positive coincidence rate was 82.9%. The other 36 lesions were negative for p-GP. For 24 patients with CR (PR), the negative coincidence rate was 66.7%. Compared with immunohistochemistry and PCR techniques, the effects of factors such as limited access and non-uniform expression of p-GP can be avoided. Conclusion 99mTc-MIBI tomography can be used as an effective supplement to p-GP qualitative examination.