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磁共振氨基质子转移成像技术已经成为一种对机体内蛋白质浓度及活性检测的新方法。目前,磁共振氨基质子转移成像序列设计主要采用预饱和激发脉冲结合回波平面成像序列采集信号,但是在高场系统中回波平面成像序列容易产生图像变形、信号丢失等问题。文章提出一种用快速梯度回波代替回波平面成像序列进行信号采集的序列设计方法,在仿体上研究了不同浓度氨基酸信号强度随预饱和脉冲偏置频率变化的关系,经过图像后处理得到了仿体的氨基质子转移图像。结果显示,仿体氨基质子转移图像无明显畸变,同时对氨基质子转移的转移率与氨基浓度做了定量分析。
Magnetic resonance proton transamination has become a new method for the detection of protein concentration and activity in the body. At present, the design of magnetic resonance proton proton transfer imaging sequence mainly uses pre-saturation excitation pulse and echo plane imaging sequence to acquire signals, but the echo plane imaging sequence in high-field system is prone to image deformation and signal loss. In this paper, we present a method of sequence design that uses fast gradient echoes instead of echographic imaging sequences for signal acquisition. The relationship between signal intensities of different concentrations of amino acids and pre-saturation pulse bias frequencies is studied on a phantom. After image post-processing, Amino proton transfer image of the fake body. The results showed that there was no obvious aberration in the image of proton transamination and the quantitative analysis of the transamination rate of amino proton transfer and the concentration of amino group.