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近年来研究发现,T细胞受体与抗原-主要组织相容性抗原复合物的结合并不能有效地激活T细胞,T细胞的活化尚需要一种辅助刺激因子。T细胞表面的CD28与抗原呈递细胞表面的B7间的作用是T细胞活化最主要的辅助刺激途径。
Recent studies have found that the combination of T-cell receptor and antigen-major histocompatibility antigen complex can not effectively activate T cells. T-cell activation still needs an auxiliary stimulus. The role of CD28 on T cell surface and B7 on the surface of antigen presenting cell is the most important auxiliary stimulus pathway for T cell activation.