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目的 探讨全身伽玛刀联合化疗治疗肺癌所致上腔静脉综合征 (SVCS)的临床疗效。方法 本组 31例SVCS均系经病理证实的肺癌病人 ,18例非小细胞肺癌先行全身伽玛刀治疗 ,再行化疗 ;13例小细胞肺癌先行化疗再行全身伽玛刀治疗 (并辅以常规外照射治疗 ) ,放疗结束后 3～ 4周再巩固化疗 1个疗程 ;同时配合消炎、利尿、抗凝等综合治疗。结果 完全缓解 (CR) 12例 ,部分缓解 (PR) 16例 ,总有效率 90 32 % ,中位缓解时间 12 8个月。结论 综合治疗肺癌所致SVCS可提高临床疗效。
Objective To investigate the clinical efficacy of total body gamma knife radiosurgery in the treatment of superior vena cava syndrome (SVCS) caused by lung cancer. Methods The 31 patients with SVCS in this study were pathologically confirmed lung cancer patients and 18 patients with non-small cell lung cancer were treated with whole-body gamma knife radiosurgery before chemotherapy. Thirteen patients undergoing primary chemotherapy with small cell lung cancer followed by whole-body gamma knife treatment Conventional external radiation therapy), 3 to 4 weeks after the end of radiotherapy to re-consolidate a course of chemotherapy; at the same time with anti-inflammatory, diuretic, anticoagulant and other comprehensive treatment. Results Complete remission (CR) in 12 cases, partial remission (PR) in 16 cases, the total effective rate was 90 32%, median remission time 12 8 months. Conclusion The comprehensive treatment of lung cancer caused by SVCS can improve clinical efficacy.