【摘 要】
:
The aim of the study was to demonstrate the degeneration of the dopaninergic nigrostriatal pathway in Parkinsons disease(PD) and Essential Tremor (ET) by using
【机 构】
:
Nuclear Medicine Department,Neurology Department
论文部分内容阅读
The aim of the study was to demonstrate the degeneration of the dopaninergic nigrostriatal pathway in Parkinsons disease(PD) and Essential Tremor (ET) by using the cocaine derivative 99mTc-TRODAT-1 SPECT and correlate the findings to the clinical severities (Hoehn and Yahr scale, H/Y). 28 patients with idiopathic Parkinsons disease, 10 patients with Essential Trenor and 19 healthy volunteers were investigated. The acquisition were performed 3 h postinjection of 99mTc-TRODAT-1, ROIs were drawn over the images of striatum and cerebellum, and ratios of striatum to cerebellar(ST/CB) were calculated. Ratios differed significantly between PD and controls, but ratios didnt show significant difference between ET patients and controls. A significant correlation didnt exist between ratios and clinical severities. Hemiparkinsons patients revealed significantly diminished 99mTc-TRODAT-1 binding not only clinically affected but unaffected side. Our findings indicated that 99mTc-TRODAT-1 SPECT is not only a reliable method to discriminate between PD and controls but also a useful tool for differential diagnosis in clinically unclear cases such as ET resembling PD.
其他文献
Objective To examine the effects of Pb2+ on N-methyl-D-aspartate (NMDA)-, K+- and quisqualate(QA)/kainite(KA)-induced increases in intracellular free calcium co
The effects of glycerol in the refolding, reactivation, unfolding, and inactivation of guanidine- denatured creatine kinase were studied by observing the fluore
Summary: Chronic treatment with Salvia Miltiorrhiza preventing left ventricular hypertrophy(LVH) and its possible mechanism-inhibiting the action of cardiac ald
目的:修订CCMD-3儿童部分,并作临床测试.方法:以ICD-10为蓝本结合国情修订,将精神发育迟滞及其它发育障碍归于70-79大类,其它行为情绪问题归于80-89类.临床测试在全国12省市1
Objective:To study the effects of low concentration of arsenic (As2O3) on DNA synthesisand related transcription factor gene E2F1 expression in keratinocyte. Me
Summary: The effects of Arecoline (Are) on calcium mobilization were investigated. In isolatedsingle ventricular myocyte of guinea pig, patch clamp whole cell r
DNA microarray is a powerful tool allowing simultaneous detection of many different target molecules in one sample. The efficiency of the array mainly depends o
A computing model employing the immune and genetic algorithm (IGA) for the optimization of part design is presented. This model operates on a population of poin
Summary: To investigate the inducement of cytotoxic T lymphocytes (CTLs) by antigen peptidesmixture from different leukemia cells and the cross-reaction of the
Objective:To observe the therapeutic effect of arsenious acid combined with Tα-1 thymuspeptide and megestrol acetate on advanced non-small cell lung cancer. Me