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目的:探讨重庆市新生儿甲状腺功能低下症(congenital hypothyroidism,CH)发病率和治疗后智能发育状况。方法:采用时间分辨免疫荧光法检测促甲状腺素(TSH)浓度。对确诊经正规治疗患儿在其2~3岁进行Gesell随访。结果:2003年1月~2008年12月筛查重庆市25个区县新生儿338 126例,检出CH患儿252例,发病率为0.75‰,男女之间差异无统计学意义,城乡之间智力水平差异有统计学意义。结论:CH患儿特别是乡村患儿早期诊断、早治疗,规范管理,进行健康教育,从而提高人口素质,减少儿童残疾发生。
Objective: To investigate the prevalence of congenital hypothyroidism (CH) and the post-treatment intelligence development in Chongqing. Methods: The concentration of thyrotropin (TSH) was measured by time-resolved immunofluorescence. Gesell follow-up was performed in children 2 to 3 years of age who were diagnosed as having regular treatment. Results: From January 2003 to December 2008, 338 126 newborns in 25 districts and counties of Chongqing were screened out. Among them, 252 cases of CH children were detected, the incidence rate was 0.75 ‰. There was no significant difference between men and women There was significant difference between intelligence levels. Conclusion: CH children, especially rural children with early diagnosis, early treatment, standardized management, health education, thereby improving the quality of population and reduce the incidence of child disability.