论文部分内容阅读
[目的]观察冻干重组人脑利钠肽(新活素)治疗急性心力衰竭患者的临床疗效。[方法]选取210例急性心衰患者,分为对照组90例,观察组120例,对照组采用常规治疗,观察组在常规治疗基础上加用新活素,观察两组治疗前后的临床症状、左室射血分数(LVEF)及血浆N-末端脑钠肽前体(NT-proBNP)水平的变化。[结果]①观察组治疗后各项指标改善均优于对照组[总有效93.3% vs 73.3%, P <0.05;显效60.0% vs 35.6%,P <0.05;治疗后 LVEF (55±12)% vs (52±11)%,P <0.05;NT-proBNP水平(1050.6±568.1) pg/mL vs (2100.8±789.2) pg/mL ,P<0.05];②观察组中,新活素治疗对急性心衰患者较慢性心衰加重患者的效果更明显[总有效97.1% vs88.0%,P <0.05;显效70.0% vs46.0%,P <0.05;治疗后LVEF (58±11)% vs (48±8)%,P <0.05;治疗后 NT-proBNP水平(780.9±365.7) pg/mL vs (1866±1075.8) pg/mL ,P <0.05]。[结论]新活素显著改善急性心衰患者的临床症状和心功能,且对急性发作心衰患者更有效。“,”[Objective]To observe clinical efficacy of lyophilized recombinant human brain natriuretic pep-tide(rhBNP) for the treatment of patients with acute heart failure .[Methods]A total of 210 patients who suf-fered from acute heart failure were chosen and divided into control group ( n=90) and observation group( n=120) .The control group was given traditional treatment ,while the observation group was given rhBNP in ad-dition to traditional treatment .The changes of clinical symptoms ,left ventricular ejection fraction (LVEF) and plasma NT-proBNP before and after treatment were observed .[Results]After treatment ,the improvement of all indexes in observation group was better than control group (total effective rate was 93 .3% and 73 .3% ,P<0 .05 ,excellent efficiency was 60 .0% and 35 .6% ,P<0 .05 ,LVEF after treatment was 55 ± 12% and 52 ± 11% ,P <0 .05 ,NT-proBNP after treatment was 1050 .6 ± 568 .1pg/mL and 2100 .8 ± 789 .2pg/mL ,P <0 .05) .In the observation group ,the efficacy in patients with acute heart failure was more obvious than that in patients with aggravated chronic heart failure (total effective rate was 97 .1% and 88 .0% ,P<0 .05 ,excellent efficiency was 70 .0% and 46 .0% ,P <0 .05 ,LVEF after treatment was 58 ± 11% and 48 ± 8% ,P <0 .05 , NT-proBNP after treatment was 780 .9 ± 365 .7pg/mL and 1866 ± 1075 .8pg/mL ,P<0 .05) .[Conclusion]The rhBNP can significantly improve clinical symptoms and cardiac function in patients with acute heart failure ,es-pecially for patients with acute onset heart failure .