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目的:观察卡前列素氨丁三醇(商品名欣母沛)在预防和治疗剖宫产产后出血中的疗效。方法:选择有产科剖宫产指征、具有潜在产后出血因素的高危产妇187例,随机分为观察组和对照组,观察组96例在剖宫产胎儿娩出后宫体注射欣母沛250μg及静脉滴注缩宫素20U,宫缩仍不佳,间隔15min继续应用欣母沛250μg。对照组91例在剖宫产胎儿娩出后给予宫体注射缩宫素20U及静脉滴注缩宫素20U,宫缩仍不佳继续应用缩宫素20～50U。比较两组术后2、24 h的出血量及产后出血的发生率。结果:观察组产后出血的发生率明显低于对照组(P<0.01),术后2、24h的平均出血量也明显减少(P<0.01)。结论:有产后出血倾向因素的剖宫产患者,应用缩宫素的同时宫体注射欣母沛,可预防和治疗产后出血,并具有快速、安全的特点,但应明确诊断,早期使用。
OBJECTIVE: To observe the curative effect of carboprost tromethamine (trade name Xinmaopei) in the prevention and treatment of hemorrhage after cesarean section. Methods: A total of 187 high risk pregnant women with indication of obstetric cesarean section and potential postpartum hemorrhage were randomly divided into observation group and control group. In observation group, 96 cases were injected intrauterine injection of Xinmupei 250μg and vein Injecting oxytocin 20U, uterine contractions are still not good, 15min intervals continue to use Yan Xin Pei 250μg. In the control group, 91 cases were given intrauterine injection of oxytocin 20U and intravenous oxytocin 20U after cesarean section fetus were delivered, and oxytocin 20 ~ 50U was continued to be used when uterine contraction was still not good. The bleeding volume and the incidence of postpartum hemorrhage were compared between the two groups at 2 and 24 hours after operation. Results: The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group (P <0.01). The mean amount of bleeding at 2 and 24 hours after operation also decreased significantly (P <0.01). Conclusion: Cesarean section patients with postpartum hemorrhagic tendency factors, the application of oxytocin at the same time the body injection of Xinma Pei, can prevent and treat postpartum hemorrhage, and has a fast and safe features, but should be clearly diagnosed, early use.