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目的 研究溃疡散对实验性大鼠胃溃疡的保护作用机制。方法 Wistar大鼠 5 0只 ,随机分为 0 .5 %羧甲基纤维素钠组、西咪替丁 (0 .5 g·kg-1)阳性对照组、溃疡散 0 .35 g、0 .7g及 1.4g·kg-13个剂量组。给药 6d后采用幽门结扎法复制大鼠胃溃疡模型 ,分别测定胃液容量、胃酸含量、胃蛋白酶活性和胃壁粘液量。结果 溃疡散 0 .7g和 1.4g·kg-1组能明显减少胃液容量 (P <0 .0 5、P <0 .0 1)和降低胃总酸排出量 (P <0 .0 0 1) ;各剂量组均能显著降低胃蛋白酶活性 (P <0 .0 1)和增加胃壁粘液量 (P <0 .0 5 ) ;各种作用呈剂量依赖性。结论 溃疡散的抗溃疡作用与增强粘膜保护因素和减少对胃粘膜的损伤因素有关。
Objective To study the protective mechanism of ulcerated ulcer on gastric ulcer in experimental rats. Methods A total of 50 Wistar rats were randomly divided into 0.5% carboxymethylcellulose sodium group, cimetidine (0. 5 g·kg-1) positive control group, ulcers scattered 0.35 g, 0. 7g and 1.4g.kg-13 dose groups. After 6 days of administration, rats’ gastric ulcer model was duplicated by pylorus ligation. Gastric juice volume, gastric acid content, pepsin activity, and gastric mucus volume were measured. Results ulcer volume 0.7g and 1.4g·kg-1 group can significantly reduce gastric fluid volume (P <0.05, P <0.01) and reduce total gastric acid output (P <0 01) Each dose group could significantly reduce the activity of pepsin (P <0.01) and increase the amount of gastric mucus (P <0.05); all effects were dose-dependent. Conclusion The anti-ulcer effect of ulcer can be related to enhancing the protective factors of mucosa and reducing the damage factors to gastric mucosa.