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目的:探讨大肠癌术后检测腹腔引流液癌胚抗原(CEA)的临床意义。方法:检测112例大肠癌患者术前与术后第1天血清CEA浓度,以及术后第1天腹腔引流液中CEA浓度,并以35例肠道良性疾病患者术后腹腔引流液CEA浓度为对照,比较大肠癌患者手术前后血清CEA浓度的变化,以及大肠癌患者与肠道良性疾病患者术后腹腔引流液CEA浓度的差异,并分析大肠癌患者腹腔引流液CEA浓度与临床病理特征的关系。结果:大肠癌患者术后第1天血清CEA浓度较术前明显下降,术后第1天腹腔引流液CEA浓度明显高于肠道良性疾病者(均P<0.05)。大肠癌患者腹腔引流液CEA浓度与肿瘤分化程度无关(P>0.05),而与肿瘤浸润深度、临床分期呈同向变化关系,且有淋巴结或远处转移者明显高于无转移者(均P<0.05)。结论:大肠癌术后检测腹腔引流液CEA浓度对判断预后具有重要参考价值。
Objective: To investigate the clinical significance of postoperative peritoneal drainage of carcinoembryonic antigen (CEA) in patients with colorectal cancer. Methods: The serum concentration of CEA in preoperative and postoperative day 1 of 112 patients with colorectal cancer and the CEA concentration in peritoneal drainage fluid on the first postoperative day were measured. The CEA concentrations in peritoneal drainage fluid of 35 patients with benign intestinal diseases were The changes of CEA concentration in patients with colorectal cancer before and after operation, CEA concentration in patients with colorectal cancer and patients with benign diseases of intestinal tract after operation, and the relationship between CEA concentration and clinicopathological features in peritoneal drainage fluid in patients with colorectal cancer . Results: The serum CEA concentration of colorectal cancer patients on the first postoperative day was significantly lower than that before the operation. The CEA concentration of peritoneal drainage fluid on the first postoperative day was significantly higher than that of benign intestinal diseases (all P <0.05). The concentration of CEA in peritoneal drainage fluid of colorectal cancer patients had no correlation with the degree of tumor differentiation (P> 0.05), but had the same trend with the depth of tumor invasion and clinical stage, and there was a significant increase in CEA with lymph node or distant metastasis <0.05). Conclusion: The detection of CEA concentration in peritoneal drainage fluid after colorectal cancer has an important reference value for judging the prognosis.