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目的 :研究潘托拉唑治疗消化性溃疡及根除幽门螺杆菌 (HP)的疗效和安全性。方法 :将经过胃镜和病理学检查证实了的消化性溃疡患者随机分成潘托拉唑组 (治疗组 )和奥美拉唑组 (对照组 )。其中治疗组 6 0例 ,应用潘托拉唑、羟氨苄青霉素和甲硝唑治疗 ;对照组 5 7例 ,应用奥美拉唑、羟氨苄青霉素和甲硝唑治疗。停药后均复查胃镜观察溃疡愈合情况以及HP根除情况。结果 :两组胃溃疡的愈合率分别为 92 3 %和 95 4% ,HP根除率分别为 92 3 %和90 9% ;十二指肠溃疡的愈合率分别为 97 1%和 94 3 % ,HP根除率分别为 91 2 %和 94 3 % ,两组比较差异无显著性 (P>0 1)。各项症状的改善情况两组相似 (P >0 1)。治疗期间两组均有良好的耐受性。结论 :潘托拉唑对消化性溃疡有很高的治愈率 ,以它为主的三联疗法可达到很高的HP根除率 ,对消化性溃疡的疗效与奥美拉唑相当 ,不良反应极少 ,患者耐受性、依从性好 ,是一种有广泛应用前景的新型质子泵抑制剂。
Objective: To study the efficacy and safety of the pantoprazole in the treatment of peptic ulcer and the eradication of Helicobacter pylori (HP). Methods: Peptic ulcer patients confirmed by gastroscopy and pathology were randomly divided into the group of pantoprazole (treatment group) and the omeprazole group (control group). The treatment group 60 cases, the application of pantoprazole, amoxicillin and metronidazole treatment; control group 57 cases, the application of omeprazole, amoxicillin and metronidazole treatment. Gastroscopy was followed up after stopping the observation of ulcer healing and HP eradication. Results: The healing rates of gastric ulcer in the two groups were 92 3% and 95 4%, respectively. The eradication rates of HP were 92 3% and 90 9% respectively. The healing rates of duodenal ulcer were 97 1% and 94 3% HP eradication rates were 91.2% and 94.3%, respectively, with no significant difference between the two groups (P> 0 1). The improvement of symptoms was similar between the two groups (P> 0 1). Both groups were well tolerated during treatment. CONCLUSION: Pantoprazole has a high cure rate for peptic ulcer. Its triple therapy can achieve high HP eradication rate, comparable efficacy to omeprazole, and minimal adverse reactions , Patient tolerance, good compliance, is a promising new proton pump inhibitor.