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目的:利用Meta分析的方法,比较黄体酮经阴道给药及肌肉注射在辅助生殖技术中黄体支持治疗的临床疗效。方法:选取发表于1990年1月至2011年12月的文献,对比分析所有比较黄体酮经阴道给药及肌肉注射治疗效果的临床随机对照试验,并应用Meta分析方法评价上述两种给药方式的临床结局。结果:共纳入13个研究2 741例患者。Meta分析的结果显示:黄体酮阴道给药组与肌肉注射组在黄体支持治疗的临床妊娠率[OR=1.09,95%CI(0.77,1.54)]、继续妊娠率[OR=1.11,95%CI(0.71,1.73)]以及流产率[OR=0.77,95%CI(0.53,1.13)]是无统计学差异的。结论:辅助生殖技术中行黄体支持治疗的两种不同给药方法:黄体酮阴道及肌肉注射给药在提高临床妊娠结局上的疗效是相似的。
OBJECTIVE: To compare the clinical efficacy of progesterone vaginal administration and intramuscular injection in the assisted reproductive technology of luteal support by Meta-analysis. METHODS: The literature published from January 1990 to December 2011 was selected to compare and analyze all clinical randomized controlled trials comparing the effects of vaginal and intramuscular injection of progesterone. Meta-analysis was used to evaluate the above two modes of administration The clinical outcome. Results: A total of 13 studies involving 2,741 patients were included. The results of Meta-analysis showed that the clinical pregnancy rate of progesterone-vaginal administration group and intramuscular injection group was higher than that of luteal support treatment group [OR = 1.09,95% CI (0.77,1.54]], and the rate of continuing pregnancy [OR = 1.11,95% CI (0.71, 1.73)] and miscarriage rate [OR = 0.77, 95% CI (0.53, 1.13)] were not statistically different. CONCLUSIONS: Two different administrations of luteal supportive therapy in assisted reproductive technology: vaginal and intramuscular administration of progesterone are similar in their efficacy in improving clinical pregnancy outcomes.