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制备聚乙二醇接枝聚乳酸(PPLA)聚合物胶束,探讨其作为药物载体的可行性和稳定性。溶剂挥发法制备PPLA胶束并对其表征。萘普生为模型药物,单因素考察了投药量、丙酮用量、加样顺序对包封率的影响。结果表明,PPLA临界胶束质量浓度(CMC)低,为3×10-4g/L;胶束呈球形、平均粒径小于200nm;在室温、稀释、碱性条件下稳定;最佳载药条件为:材料与药物同时溶于丙酮后滴入水中、丙酮与水的体积比1∶10,萘普生与PPLA质量比0.8∶10,PPLA胶束质量浓度1.0g/L。37℃时载药胶束在磷酸盐缓冲液(PBS)中可缓慢持续释放5d以上。结果证明,制备的聚乙二醇接枝改性聚乳酸聚合物胶束可用作疏水性药物的缓释给药载体。
Preparation of polyethylene glycol graft polylactic acid (PPLA) polymer micelles to explore its feasibility and stability as a drug carrier. Solvent evaporation method was used to prepare PPLA micelles and characterize them. Naproxen as a model drug, single factor investigated the dosage, the amount of acetone, sample loading sequence on the encapsulation efficiency. The results showed that the critical micelle concentration (CMC) of PPLA was as low as 3 × 10-4g / L. The micelles were spherical and the average diameter was less than 200nm. The micelles were stable at room temperature, diluted and alkaline conditions. The volume ratio of acetone to water was 1:10, the mass ratio of naproxen to PPLA was 0.8:10, and the mass concentration of PPLA micelles was 1.0 g / L. At 37 ℃, drug-loaded micelles can be sustainedly released for more than 5 days in phosphate buffered saline (PBS). The results show that the prepared polyethylene glycol graft modified polylactic acid polymer micelles can be used as a sustained-release drug delivery carrier for hydrophobic drugs.