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目的探讨奥沙利铂为主的化疗联合腹腔温热灌注治疗晚期肠癌的临床效果。方法对42例晚期大肠癌患者,予腹腔温热灌洗化疗及体外高频透热治疗,联合以奥沙利铂为主的静脉化疗,至少2个周期,观察疗效及不良反应。结果全组患者完成169个周期治疗,CR5例,PR22例,SD8例,PD7例,总有效率66.3%,完全缓解率11.9%。不良反应以白细胞下降及消化道反应多见,少数患者出现周围性神经毒性,以Ⅰ-Ⅱ度为主。结论以奥沙利铂为主的静脉化疗联合腹腔温热灌注和体外高频透热治疗,对晚期大肠癌具有一定的疗效,毒副作用小;腹腔局部化疗是一种值得关注的治疗途径。
Objective To investigate the clinical effect of oxaliplatin-based chemotherapy combined with intraperitoneal hyperthermic perfusion in the treatment of advanced colorectal cancer. Methods Forty-two patients with advanced colorectal cancer were treated with intraperitoneal hyperthermic lavage chemotherapy and in vitro high-frequency diathermy, and oxaliplatin-based intravenous chemotherapy was used for at least 2 cycles to observe the efficacy and adverse reactions. Results The whole group of patients completed 169 cycles of treatment, including CR5, PR22, SD8 and PD7. The total effective rate was 66.3%, and the complete remission rate was 11.9%. Adverse reactions were mostly seen in leukopenia and gastrointestinal reactions, and a few patients had peripheral neurotoxicity, mainly I-II degree. Conclusions The combination of oxaliplatin-based intravenous chemotherapy with intraperitoneal hyperthermic perfusion and in vitro high-frequency diathermy has a certain curative effect on advanced colorectal cancer with low toxicity and side effects; intraperitoneal local chemotherapy is a therapeutic approach worthy of attention.