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在1950年间,Hamre 等开始系统地寻找抗病毒物质。50年代和60年代早期,随机筛选取得的经验是当时研究的内容。甚至现在,这种筛选抗病毒物质的方法仍不失它的意义。然而,由于有关病毒的结构和生物学特性的进一步认识,以及在近几年里对初期一些有效的抗病毒物质的作用机制的发现.在理论指导的基础上研究常常具有较重要的地位。
In 1950, Hamre and others began to systematically search for antiviral substances. In the 1950s and early 1960s, the experience gained by random screening was the subject of the study. Even now, this method of screening anti-viral substances does not lose its meaning. However, due to the further understanding of the structural and biological characteristics of the virus, and the discovery of the mechanism of action of some effective antiviral agents in the early years, it is often more important to conduct research based on theoretical guidance.