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目的探讨血清和龈沟液中白细胞介素(IL)-6含量与绝经妇女牙周炎的关系。方法选择2010年8月至2011年1月广东省深圳市龙岗中心医院耳鼻咽喉科分院口腔科牙周炎初诊绝经女性患者20例(患牙20颗),检查并记录治疗前和治疗后4周患牙的牙龈指数(GI)、牙周探诊深度(PD)、附着丧失(AL),采集治疗前和治疗后4周患者的血清和患牙龈沟液并用酶联免疫吸附法(ELISA)测定其IL-6质量浓度。结果牙周基础治疗后患牙龈沟液中IL-6质量浓度较治疗前明显降低,差异有统计学意义(t=3.015,P<0.01);患者血清中IL-6阳性率在治疗前后的差异无统计学意义(χ2=1.056,P>0.05)。治疗后各项牙周指标(GI、PD、AL)均较治疗前降低,差异有统计学意义(均P<0.05)。结论牙周基础治疗对患牙周炎的绝经妇女牙周局部IL-6含量有影响,而对其血液IL-6含量无影响。
Objective To investigate the relationship between interleukin (IL) -6 in serum and gingival crevicular fluid and periodontitis in postmenopausal women. Methods From August 2010 to January 2011, 20 cases of newly diagnosed postmenopausal women with oral cavity periodontitis in Longgang Central Hospital of Shenzhen City, Guangdong Province were enrolled in this study. Pre-treatment and post-treatment 4 weeks Gingival index (GI), periodontal exploration depth (PD) and attachment loss (AL) of the affected teeth were measured. Serum and gingival crevicular fluid were collected from the patients before and after 4 weeks of treatment and were measured by enzyme-linked immunosorbent assay (ELISA) Its IL-6 mass concentration. Results The concentration of IL-6 in gingival crevicular fluid after periodontal basic treatment was significantly lower than that before treatment (t = 3.015, P <0.01). There was no significant difference in the serum IL-6 positive rate between before and after treatment Statistical significance (χ2 = 1.056, P> 0.05). All the indexes of periodontal disease (GI, PD, AL) after treatment were lower than those before treatment, the difference was statistically significant (all P <0.05). Conclusion Periodontal basic treatment has an effect on the level of IL-6 in periodontal tissue of menopausal women with periodontitis, but has no effect on the level of IL-6 in blood.