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【目的】探讨原始神经外胚瘤（ＰＮＥＴ）与其它恶性小细胞肿瘤的鉴别要点。【方法】应用免疫组化ＳＰ法对１４例ＰＮＥＴ进行免疫组化标记，同时结合临床病理资料进行分析。【结果】１４例ＰＮＥＴ中，除胸壁３例外，其余的均沿身体纵轴分布，为一界限性肿块，瘤细胞密集呈巢状排列，常被致密纤维组织分隔成分叶状或腺泡状，可见神经性玫瑰花形物形成；免疫组化神经性标记至少２项以上阳性。【结论】临床病理学观察结合免疫组化，在ＰＮＥＴ与其它恶性小细胞肿瘤的鉴别诊断中有重要意义。
【Objective】 To explore the main points of differentiating primitive neuroectodermal tumor (PNET) from other malignant small cell tumors. 【Methods】 14 cases of PNET were immunohistochemically labeled with immunohistochemical SP method and analyzed with clinicopathological data. 【Results】 The results of 14 cases of PNET, except for the chest wall in 3 cases, the rest are distributed along the longitudinal axis of the body, as a limiting mass, neoplasm densely arranged in nests, often divided by dense fibrous tissue into leaf or alveolar, Visible neurological rose flower formation; immunohistochemical neurological markers at least two positive. 【Conclusions】 Clinicopathological observation combined with immunohistochemistry is of great significance in the differential diagnosis of PNET and other malignant small cell tumors.