青年女性,临床表现反复四肢无力,血压偏低,伴低血钾、代谢性碱中毒,血镁正常、肾素-血管紧张素-醛固酮系统(RAAS)激活,血清肌酐升高,低尿钙,24h尿蛋白定量及尿沉渣红细胞计数均在正常范围。肾活检示肾小球球旁器肥大,肾小管间质重度慢性病变合并轻度急性病变。最终诊断Gitelman综合征相关肾损害。 Young women, clinical manifestations of repeated weakness, low blood pressure, with hypokalemia, metabolic alkalosis, normal blood magnesium, activation of renin - angiotensin - aldosterone system (RAAS), elevated serum creatinine, low urinary calcium, 24h urinary protein and urine sediment count of erythrocytes in the normal range. Renal biopsy showed glomerular globular hypertrophy, tubulointerstitial severe chronic disease with mild acute lesions. Final diagnosis of Gitelman syndrome-related renal impairment.