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正常妊娠胚胎作为半同种移植物之所以能够维持,取决于母胎界面免疫耐受的形成。树突状细胞(dendriticcells,DC)作为体内最重要的抗原提呈细胞,处于免疫应答的中心环节,不但具有激发免疫应答的能力,还可以下调免疫应答或诱导免疫耐受的产生。妊娠期间雌孕激素水平的改变也可能影响到树突状细胞的分化、成熟及功能,有利于妊娠的维持。本文就树突状细胞在妊娠免疫耐受中的作用作一综述。
Normal pregnancy embryos as semi-allografts are able to maintain, depends on the formation of immune tolerance at the maternal-fetal interface. As the most important antigen-presenting cell in the body, dendritic cells (DCs) are the central part of immune response, which not only has the ability to stimulate the immune response, but also can down-regulate the immune response or induce the immune tolerance. Changes in the level of estrogen and progesterone during pregnancy may also affect the differentiation, maturation and function of dendritic cells, which is conducive to the maintenance of pregnancy. This article reviews the role of dendritic cells in pregnancy immune tolerance.