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目的:对新生儿退黄合剂进行剂型改良,改变给药途径,探讨其对新生儿黄疸的临床治疗效果。方法:采用水提醇沉法制备新生儿退黄合剂、新生儿退黄洗剂和灌肠液。将符合纳入标准的病例采用随机分组平行对照法,分为观察组A,B和对照组,各60例。对照组给予苯巴比妥钠口服;观察组A给予新生儿退黄合剂口服;观察组B退黄液灌肠同时给予退黄洗剂药浴。比较3组治疗有效率,检测血清胆红素,评价其退黄效果。结果:灌肠联合药浴组与对照组比治疗有效率提高,血清胆红素值下降,差异有统计学意义(P<0.01);与口服退黄合剂组相比总有效率提高(P<0.05)。结论:中药灌肠联合药浴治疗新生儿黄疸有效率高,同时克服了新生儿口服药物的不便,值得临床推广应用。
OBJECTIVE: To improve the formulation of neonatal jaundice mixture, change the route of administration, and discuss its clinical treatment effects on neonatal jaundice. Methods: The neonatal jaundice mixture, neonatal jaundice lotion and enema were prepared by water extraction and alcohol precipitation. Cases that meet the inclusion criteria were randomly divided into groups of parallel controls. They were divided into observation group A, B, and control group, 60 cases each. The control group was given phenobarbital sodium orally; the observation group A was administered orally with neonatal jaundice mixture; the observation group B was given an emascant enema while a jaundice lotion medicinal bath was given. The efficacy of the three groups was compared, serum bilirubin was detected, and its yellowing effect was evaluated. Results: Compared with the control group, the efficiency of treatment with enema combined medicated bath group was improved, serum bilirubin value was decreased, the difference was statistically significant (P<0.01), and the total effective rate was improved compared with the group of oral huanghuang mixture (P<0.05). ). Conclusion: Chinese medicine enema combined with medicinal bath is effective in the treatment of neonatal jaundice. It also overcomes the inconvenience of neonatal oral medication and is worthy of clinical application.