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约于30年前已证实,5-HT 通过两种不同的机理引起豚鼠回肠收缩,即直接活化平滑肌细胞或间接引起壁内胆碱神经释放ACh。1957年Gaddum 等又证明,苯氧苄胺(Dibenzyline;D)能阻滞平滑肌细胞上的5-HT 受体;吗啡(M)则抑制5-HT 兴奋神经元和释放ACh 所引起的收缩作用。因而设想,平滑肌细胞上5-HT受体是D 受体,而胆碱神经上5-HT 受体是M受体,这是首次从药理学角度证明存在不同的5-HT 受体亚型,但苯氧苄胺和吗啡都不能在
About 30 years ago, 5-HT has been shown to induce ileal contractions in guinea-pigs by two distinct mechanisms, either directly activating smooth muscle cells or indirectly causing intra-parietal cholinergic nerve release of ACh. In 1957, Gaddum et al. Demonstrated that Dibenzyline (D) blocks 5-HT receptors on smooth muscle cells while morphine (M) inhibits the contraction induced by 5-HT-stimulated neurons and ACh release. It is therefore assumed that the 5-HT receptor on smooth muscle cells is the D receptor and the cholinergic 5-HT receptor on the M receptor, which for the first time proves the existence of different 5-HT receptor subtypes from a pharmacological point of view, But phenoxybenzamine and morphine can not be