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目的:探讨急性脑梗死与颈动脉粥样硬化斑块及基质金属蛋白酶9(MMP9)水平的临床相关性。方法:对108例急性脑梗死患者采用美国GE Ultrasound Vivid 7型彩色多普勒超声行颈动脉超声检测,并检测血清MMP9水平。结果:病例组58例中软斑块42例,对照组50例中软斑块11例,两组斑块发生率比较有统计学意义(P<0.05);病例组MMP9水平较对照组明显升高,有统计学意义(P<0.05)。结论:颈动脉粥样硬化斑块与脑梗死发病有相关性,斑块的易损性与脑梗死关系密切。
Objective: To investigate the clinical correlation between acute cerebral infarction and carotid atherosclerosis plaque and matrix metalloproteinase 9 (MMP9) levels. Methods: 108 cases of patients with acute cerebral infarction were examined by carotid ultrasound with GE Ultrasound Vivid 7 color Doppler ultrasound. Serum MMP9 level was measured. Results: There were 42 cases of soft plaque in 58 cases in the case group and 11 cases of soft plaque in 50 cases in the control group. The incidence of plaque in the two groups was statistically significant (P <0.05). The MMP9 level in the case group was significantly higher than that in the control group There was statistical significance (P <0.05). Conclusion: The incidence of carotid atherosclerosis plaque is correlated with cerebral infarction. The vulnerability of plaque is closely related to cerebral infarction.