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患典型偏头痛时,在前驱期,最初的特点之一是血浆去甲肾上腺素增加.多数患者的血小板聚集作用持续增强.去甲肾上腺素可以加强这一异常现象而释放5-羟色胺和二磷酸腺苷(ADP).这些物质又可反复地促使血小板进一步聚集.5-羟色胺对血管的作用复杂,它能导致动脉收缩,毛细血管扩张;5-羟色胺减少时则恰好相反.5-羟色胺使血脑屏障通透性增加,因而促进其进入脑内.结果,动脉收缩引起一系列神经功能障碍—典型表现在视觉方面.随之血5-羟色胺减少而失去其对血管的持续收缩作用.这可能导致颅外血管扩张性头痛,但颅外血流量增加并不是引起头痛的唯一原因:
One of the first signs of migraine with typical migraine during the prodromal phase is an increase in plasma norepinephrine, which continues to increase in most patients. Norepinephrine enhances this anomalous release of serotonin and diphosphate Adenosine (ADP) .This substance can repeatedly promote further platelet aggregation.Serotonin on vascular function is complex, it can lead to arterial contraction, telangiectasia; 5-HT decreases exactly the opposite .5-HT makes the blood As a result, arterial constriction causes a series of neurological dysfunctions - a typical manifestation of which is visual, with consequent loss of serotonin and loss of its sustained vasoconstriction, which may be due to increased permeability of the brain barrier, thereby promoting its entry into the brain Leading to extracranial vasodilatory headache, but increased extracranial blood flow is not the only cause of headache: