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目的:探讨注射用α-硫辛酸对2型糖尿病早期肾病(DN)的保护作用。方法:将56例2型糖尿病早期肾病患者随机分为治疗组28例,采用注射α-硫辛酸加常规治疗;对照组28例,仅给予常规治疗。治疗前后测定尿微量白蛋白排泄率(UAER)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平。结果:与治疗前比较,治疗组UAER及MDA均显著降低(P<0.05),SCr、SOD及NO显著升高(P<0.05)。对照组SCr、UAER、SOD、MDA及NO与治疗前比较差异无统计学意义(P>0.05)。结论:注射用α-硫辛酸能减少2型糖尿病肾病患者尿微量白蛋白的排泄,对早期肾病具有保护作用。
Objective: To investigate the protective effect of α-lipoic acid for injection on early nephropathy (DN) in type 2 diabetic patients. Methods: 56 cases of type 2 diabetic patients with early nephropathy were randomly divided into treatment group 28 cases, the injection of α-lipoic acid plus conventional treatment; control group of 28 patients, only given routine treatment. Urinary microalbuminuria (UAER), superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) levels were measured before and after treatment. Results: Compared with those before treatment, the levels of UAER and MDA in the treatment group were significantly decreased (P <0.05) and the levels of SCr, SOD and NO were significantly increased (P <0.05). There was no significant difference in SCr, UAER, SOD, MDA and NO between the two groups before treatment (P> 0.05). CONCLUSION: Alpha-lipoic acid for injection reduces the excretion of urinary albumin in patients with type 2 diabetic nephropathy and has a protective effect on early nephropathy.