近年来,有人将抗组胺药分为传统的抗组胺药和新型抗组胺药,息斯敏就是新型抗组胺药的代表性品种。息斯敏与H_1受体有很强的亲合力,而且有高度的选择性。息斯敏是一种长效制剂,在体内的主要代谢产物是去甲基阿司咪唑,后者和息斯敏一样也具有抗组胺活性。息斯敏及其代谢产物与H_1受体结合后解离速度甚慢,这是它作用持久的基本原因。药代动力学研究表明,在连续服用息斯敏后,息斯敏和去甲 In recent years, some people have divided antihistamines into traditional antihistamines and new antihistamines. Astemizole is a representative variety of new antihistamines. Astemizole has a strong affinity with the H 1 receptor and has a high degree of selectivity. Astemizole is a long-acting formulation and the major metabolite in the body is desmethylastemizole, which also has antihistamine activity as well as astemizole. Aspartame and its metabolites and H 1 receptor binding dissociation rate is very slow, which is the basic reason for its long-lasting effect. Pharmacokinetic studies show that after taking astemizole, astemizole and noradrenaline